Mitochondria-derived damage-associated molecular patterns (DAMPs) are a proposed link between age-related mitochondrial damage and age-related inflammation, and this open access paper outlines present thinking on the topic. Mitochondria, the power plants of the cell, are strongly implicated in the progression of aging in a number of ways, the SENS view of damage to mitochondrial DNA producing dysfunctional cells being one, and a more general decline in mitochondrial energy generation for other reasons, yet to be fully mapped, being another. ...

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Ayurveda is fast-becoming a preferred lifestyle option around the world, and it is poised for a quantum leap today as Western companies realize its potential and Western consumers realize its benefits. Ayurveda is the age-old science of well-being, which has the benefit of making consumers look younger and feel vibrant. ...

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Scientists at Sanford Burnham have identified the mechanism that causes muscle cells to stop regenerating as people age. This knowledge could lead to methods to slow—but not stop—the decline in muscle mass and function people experience as they get older. ...

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USC and Los Angeles experts discussed the ways the environment shapes aging, the remarkable progress made in improving Los Angeles’ social and physical environment and the region’s ambitious goals for supporting an aging populace during the USC Leonard Davis School of Gerontology’s annual What’s Hot in Aging Research symposium on April 19. As he welcomed attendees, USC Davis School Dean Pinchas Cohen said the annual event, much like interest in the wider field of gerontology itself as well as the USC Davis School’s programs, has steadily grown over the years. ...

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Among the complex determinants of aging, mitochondrial dysfunction has been in the spotlight for a long time. As the hub for many cellular functions, the maintenance of an adequate pool of functional mitochondria is crucial for tissue homeostasis. ...

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Nobel Prize laureate Elizabeth Blackburn discovered that a tiny piece of our chromosomes holds the secret to why we age. It’s a special region on the ends of our chromosomes that becomes shorter every time it replicates inside our body. ...

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Calico’s logo is a labyrinth — fitting for the ultra-secretive company. Researchers are puzzled by Calico’s stealthiness and say it’s not good for science. ...

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As a topic for aging research, cellular senescence passed its tipping point a few years ago. Prior to that growth of interest and attention it was a struggle to raise funding for this area of work, and thus it didn't matter how compelling the evidence was for its involvement in the processes of aging. ...

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Ageing skeletal muscle undergoes chronic denervation, and the neuromuscular junction (NMJ), the key structure that connects motor neuron nerves with muscle cells, shows increased defects with ageing. Previous studies in various species have shown that with ageing, type II fast-twitch skeletal muscle fibres show more atrophy and NMJ deterioration than type I slow-twitch fibres. ...

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Decades ago, scientists surgically attached pairs of rats to each other and noticed that old rats tended to live longer if they shared a bloodstream with young rats. It was the beginning of a peculiar and ambitious scientific endeavor to understand how certain materials from young bodies, when transplanted into older ones, can sometimes improve or rejuvenate them. ...

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